承担课题研究
在美国期间,主持美国心脏学会基金2项,美国NIH心脏、肺及血液研究所 R01基金一项,共同主持美国NIH关节炎、骨骼肌及皮肤病研究所R01基金一项,共计研究经费390万美元。参与美国NIH国家科研资源中心仪器资助基金一项、多中心研究基金一项,研究经费逾400万美元。
自2014年回国后,主持国家自然科学基金面上项目4项、参与国家自然科学基金专项基金1项。主持上海市科委浦江人才计划1项、参与上海市科委基金项目1项。资助金额总计367万。航天南科大冷冻电镜中心联合实验室等横向科研经费520万元。
1988-1993 清华大学生物科学与技术系,生物科学与技术专业,获理学学士学位,导师隋森芳院士
1990-1993 清华大学经济管理学院,企业管理专业,管理学第二学士学位
1993-1997 清华大学生物科学与技术系,生物物理学专业,获理学博士学位,导师隋森芳院士。
代表文章 (*通讯作者)
主要研究方向为结构生物学、病毒学、细胞生物学与心血管疾病。迄今已发表研究论文52篇;其中SCI论文46篇。SCI论文中第一作者7篇,通讯作者30篇。
1. Zheng Liu*, Jing Zhang, Manjuli R. Sharma, Pin Li, S. R. Wayne Chen, and Terence Wagenknecht (2001) Three-dimensional reconstruction of the recombinant type 3 ryanodine receptor and localization of its amino terminus. Proceedings of the National Academy of Sciences of the United States of America, 98: 6104-6109.
2. Aojie Wang, Feng Zhou, Congcong Liu, Dongsheng Gao, Ruxi Qi, Yiheng Yin, Sheng Liu, Yuanzhu Gao, Lutang Fu, Yinhe Xia, Yawei Xu, Chuanqing Wang*, and Zheng Liu* (2022) Structure of infective Getah virus at 2.8 Åresolution determined by cryo-electron microscopy. Cell Discovery, 8: 12.
3. Cong Sun, Yin-Feng Kang, Yuan-Tao Liu, Xiang-Wei Kong, Hui-Qin Xu, Dan Xiong, Chu Xie, Yi-Hao Liu, Sui Peng, Guokai Feng*, and Zheng Liu* and Mu-Sheng Zeng* (2022) Parallel profiling of antigenicity alteration and immune escape of SARS-CoV-2 Omicron and other variants. Signal Transduction and Targeted Therapy, 7: 42.
4. Yanqun Wang, An Yan, Deyong Song, Chuangchuang Dong, Muding Rao, Yuanzhu Gao, Ruxi Qi, Xiaomin Ma, Qiaoping Wang, Hongguang Xu, Hong Liu, Jing Han, Maoqin Duan, Shuo Liu, Xiaoping Yu, Mengqi Zong, Jianxia Feng, Jie Jiao, Huimin Zhang, Min Li, Beibei Yu, Yanxia Wang, Fanhao Meng, Xiaodan Ni, Ying Li, Zhenduo Shen, Baiping Sun, Xin Shao, Haifeng Zhao, Yanyan Zhao, Rui Li, Yanan Zhang, Guangying Du, Jun Lu, Chunna You, Hua Jiang, Lu Zhang, Lan Wang*, Changlin Dou*, Zheng Liu*, and Jincun Zhao* (2023) Biparatopic antibody BA7208/7125 effectively neutralizes SARS-CoV-2 variants including Omicron BA.1-BA.5. Cell Discovery, 9: 3.
5. Xiaoyu Ma, Yanqun Wang, Yuanzhu Gao, Yiliang Wang, An Yan, Jiantao Chen, Lu Zhang, Peiyi Wang, Jincun Zhao*, and Zheng Liu* (2023) Structural characteristics of the SARS-CoV-2 Omicron lineages BA.1 and BA.2 virions. Signal Transduction and Targeted Therapy, 8: 131.
学术专著
1. Zheng Liu and Terence Wagenknecht (2005) Three-dimensional reconstruction of ryanodine receptors. In Ryanodine Receptors: Structure, Function and Dysfunction in Clinical Disease. (Wehrens, Xander H. T.; Marks, Andrew R., Eds.) pp. 25-34, Springer Press, New York, NY.
2. Terence Wagenknecht and Zheng Liu (2010) Electron microscopy of ryanodine receptors. In Current Topics in Membranes, Vol.66: Structure-Function of Ca2+ release channels. (Irina Serysheva Ed.) pp. 27-47, Academic Press, Burlington, MA.
学术奖励
国家教委科技进步一等奖
国家教委科技进步三等奖
清华大学基础性研究成果奖